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Biologics Revolutionize Psoriatic Arthritis Treatment

By Garippo, Gina
Content provided by: Better Medicine from Healthgrades

In the past 10 years, the treatment of psoriatic arthritis has dramatically improved thanks to the creation of biologic response modifier (or biologic) drugs. Biologics, which are made from living things such as human and animal proteins, target specific areas of the immune system that cause psoriatic arthritis. The drugs have offered tremendous hope for those with moderate to severe psoriatic arthritis, providing treatment success, usually without serious side effects.

Biologic Drugs at Work

Unlike other systemic treatments for psoriatic arthritis that affect the entire immune system, biologic drugs are designed to weaken or block only certain parts of the immune system, called tumor necrosis factor-alpha (TNF-alpha) molecules. TNF-alpha, a substance created in excess by people with psoriatic arthritis, triggers inflammation, which leads to joint damage, pain, stiffness, and swelling.

Some biologic drugs prescribed for psoriatic arthritis are given by self-injection weekly or monthly, but others require injection or infusion at the doctor’s office. Biologics effective in treating psoriatic arthritis currently include:

Understanding the Benefits and Risks

Biologic drugs have been shown to significantly improve symptoms of psoriatic arthritis for most people without causing unwanted side effects such as organ damage. The drugs have also been shown to slow or prevent disease-related joint damage.

Biologic drugs are fairly new, and it’s important to know that long-term research on potential risks is not available. Because biologics target the immune system, risk for infection is still a concern. Studies on individuals with rheumatoid arthritis who have taken the drugs for at least 10 years have not found any major problems. 

Limitations to Biologics

Despite the treatment success of biologic drugs for people with psoriatic arthritis, they aren’t available for every person with the disease. One reason is that they are extremely expensive and not affordable without good health insurance. Even then, many insurers require patients to try “traditional” disease-modifying antirheumatic drugs (DMARDs) first.

To learn if biologics could benefit you, talk with your doctor. Psoriatic arthritis affects each person differently. Your doctor will create a treatment plan based on your individual condition and needs. 

Key Takeaways:

  • Biologics are made from living things such as human and animal proteins and target specific areas of the immune system that cause psoriatic arthritis.

  • Biologics have been shown to significantly improve symptoms usually without causing major side effects.

  • These drugs are expensive and may not be appropriate for all people with psoriatic arthritis. Talk with your doctor about including biologics in your treatment plan.

Medical Reviewer: William C. Lloyd III, MD, FACS Last Annual Review Date: Dec. 15, 2013 Copyright: © Copyright 2013 Healthgrades, Inc. All rights reserved. May not be reproduced or reprinted without permission from Healthgrades, Inc. Use of this information is governed by the Healthgrades User Agreement.

Reference: Skin, Hair and Nails section on Better Medicine


This content is selected and managed by the HealthGrades editorial staff.

Did You Know?

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Psoriatic arthritis occurs equally in both sexes, and tends to come on about 10 years after the original diagnosis of psoriasis.